Bacterial challenges and evolving antibacterial drug strategy.
نویسندگان
چکیده
منابع مشابه
Bacterial challenges and evolving antibacterial drug strategy.
In this paper, we attempt to summarize developments ofimportance for practising hospital clinicians and for primary care doctors who must be aware of the ever-widening spectrum of recognized pathogens. This article is restricted to considerations of pathogenic bacteria and antibacterial drugs that have obliged us to change our strategies or policies in the last decade or so. There have been man...
متن کاملBiofilms: An Evolving and Universal Evasive Strategy of Bacterial Pathogens
The surfaces of bacterial cells are perhaps the most important structure in bacteria because they are in immediate contact with the external environment. When bacteria are examined in natural environments they exist as suspended growth forms known as “Planktons”. Planktonic forms often are highly motile, have unnatural access to nutrients and multiply rapidly. Also they are more susceptible to ...
متن کاملThe evolving role of chemical synthesis in antibacterial drug discovery.
The discovery and implementation of antibiotics in the early twentieth century transformed human health and wellbeing. Chemical synthesis enabled the development of the first antibacterial substances, organoarsenicals and sulfa drugs, but these were soon outshone by a host of more powerful and vastly more complex antibiotics from nature: penicillin, streptomycin, tetracycline, and erythromycin,...
متن کاملBacterial Transcription as a Target for Antibacterial Drug Development.
Transcription, the first step of gene expression, is carried out by the enzyme RNA polymerase (RNAP) and is regulated through interaction with a series of protein transcription factors. RNAP and its associated transcription factors are highly conserved across the bacterial domain and represent excellent targets for broad-spectrum antibacterial agent discovery. Despite the numerous antibiotics o...
متن کاملevolving bacterial population
Recently, Lenski et al have carried out an experiment on bacterial evolution. Their findings support the theory of punctuated equilibrium in biological evolution. We show that the M=2 Bak-Sneppen model can explain some of the experimental results in a qualitative manner. There are two major schools of thought in evolutionary biology: gradualism which implies continuous evolutionary changes and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1992
ISSN: 0032-5473
DOI: 10.1136/pgmj.68.795.6